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Why Fatty Liver Disease Matters


Non-alcoholic fatty liver disease (NAFLD) is a medical term related to a condition caused by a build-up of fat in liver cells, aka fatty liver. In a healthy body, the liver removes toxins and produces bile, a protein that breaks down fat into fatty acids to be digested. Fatty liver disease causes damage to the liver and prevents it from working.

Why is this important? For most people, having fatty liver may not cause an illness but if left untreated and progresses it can cause injury to liver cells. NAFLD can also be considered high risk in certain individuals that may suffer from the conditions listed below. For example:

  • Obesity or overweight, and if you carry a lot of your weight in your midsection
  • Type 2 diabetes
  • PCOS
  • High blood pressure
  • Underactive thyroid
  • High cholesterol
  • Metabolic syndrome (a combination of diabetes, high blood pressure, and obesity)
  • Smoke
  • Over the age of 50

The main stages of NAFLD are :

  1. Simple fatty liver is also known as non-alcoholic fatty liver (NAFL and steatosis). NAFL is when there is fat buildup in the liver cells but with little or no inflammation or liver damage. NAFL typically does not progress to cause liver damage or complications. However, NAFL can cause pain from enlargement of the liver. Most people will develop this first stage without knowing.
  2. Non-alcoholic steatohepatitis (NASH) is a more severe form of NAFLD in which there is inflammation of the liver and liver damage. It is important to note that there is still a buildup of fat in the liver in addition to inflammation. The inflammation and liver damage can cause scarring of the liver. NASH may lead to cirrhosis.
  3. Fibrosis can be developed from NASH and the continued inflammation of the liver. Fibrosis is the buildup of scar tissue around the liver and blood vessels. The excess scar tissue can block blood flow to parts of your liver.
  4. Cirrhosis is the most severe and irreversible stage. This occurs when the liver is under prolonged inflammation. The buildup of scar tissue causes permanent damage to the liver which can lead to liver failure and liver cancer. This is the stage where a liver transplant may be necessary.

Knowing the difference between the stages and types of fatty liver disease is important because most people with fatty liver do not realize it. Many individuals with simple fatty liver do not experience any sickness, symptoms, or inflammation that occurs in the more developed stages of fatty liver disease. This characteristic of simple fatty liver can be dangerous because it can quickly progress to more severe stages. The risk of progression is high in non-alcoholic fatty liver disease.

Prevention and being proactive are key to stopping the progression of fatty liver disease. There are currently no specific medications for NAFLD, but the most effective treatments so far are lifestyle changes. Implementing more healthy habits like limiting alcohol, added sugars, and saturated fats; losing weight, and consuming more nutrient-dense foods are important in decreasing your risk and helping the management of NAFLD. Getting screened for NAFLD and having regular appointments with your health professional are other crucial steps to take for optimal liver health.

For additional content related to working with clients or patients regarding health, nutrition, or wellness issues, visit OneOp Nutrition and Wellness. Free CEUs are available for RDNs through our webinars.

Written By:
Megan Ng, Graduate Student of Food Science and Human Nutrition at the University of Illinois at Urbana Champaign

Edited By:
Kristina Adams Smith, MS, RD, LDN
Program Coordinator



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This technology is supported in part by New Technologies for Ag Extension (funding opportunity no. USDA-NIFA-OP-010186), grant no. 2023-41595-41325 from the USDA National Institute of Food and Agriculture. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the U.S. Department of Agriculture or the Extension Foundation. For more information, please visit You can view the terms of useat

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